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. 35.19. . I, -. . -, II. . I . II . . 35.15.(Redrawn and reproduced, with permission, from Smith L. H. Ir. Pyrimidine metabolism in man. N. Engl. Med. 1973, 288, p. 764) . , , . , , , .

6- 6- -, .

( ) . , , , , .

Ames . N. et al. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: A hypothesis, Proc. Natl. Acad. Sci. USA, 1981, 78, 6858.

Henderson J. F. Regulation of Purine Biosynthesis, Monograph, No. 170, American Chemical Society, 1972.

Henderson J.F., Paterson A.R.P. Nucleotide Metabolism: An Introduction, Academic Press, 1973.

Jones M. Pyrimidine nucleotide biosynthesis in animal cells, Annu. Rev. Biochem., 1980, 49, 253.

Kempe T. D. et al. Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis, Cell, 1976, 9, 541.

Martin D. W. Jr., Gelfand E. W. Biochemistry of diseases of im-munodevelopment, Annu. Rev. Biochem., 1981, 50, 845.

Smith L.H. Jr. Pyrimidine metabolism in man, N. Engl. J. Med., 1973, 288, 764.

Stanbury J. B. et al. (eds.) The Metabolic Basis of Inherited Disease, 5th ed., McGraw-Hill, 1983.

Thelander L., Reichard P. Reduction of ribonucleotides, Annu. Rev. Biochem., 1979, 48, 133.

Wyngaarden J. B., Kelley W. N. Gout and Hyperuricemia, Gru-ne and Stratton, 1976.

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