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, . . , - -. ( ) -L- (GleUA) 5-, - (IdUA). , -, - ( ).

3 :

1) - ; 2) - - II; GlcNAc

, . 1 1-Ser-O- . - , -. - GlcNAc - , -З -, , , - . .

, , . . , . , , .

: 1) -; 2) , ; 3) , .

, , - .

. , - , . 14. . , . , , . , - .

7 (-)

. 54.9. - ; IdUA - L- ; GlcN - D-; GalN-D-; Ac-; Gal-D-; Xyl- D-; Ser-L-; Thr-L-; Asn - L ; Man - D-; NeuAc-N- ). , , , , , L-, D- . , : . 2- , . (Slightly modified and reproduced, with permission, from Lcnnarz W. J. The Biochemistry of Glycoproteins and Proteoglycans, Plenum Press. 1980.)

. , ; , . , , . 7 , , .

. .

7 , , . 54.9.

, GlcUA GlcNAc. ( ) , , , , . , , .

, . - Xyl-Ser. . 54.9. , , GalNAc, GlcNAc. , GlcUA, . GalN

. 54.10. ; . (Reproduced, with permission, from Rosenberg L., Heilman W., Kleinschmidt A. K. Electron microscopic studies of proteoglycan aggregates from bovine articular cartilage. J. Biol. Chem., 1975, 250, 1877.)

4 6. , , . . 40 , 20000. . .

, . (. 54.10); . 54.11 .

, .

. 54.11. - . (Reproduced, with permission, from Len-narz W.J. The Biochemistry of Glycoproteins and Proteoglycans. Plenum Press, 1980.)

6 , 6 . , 2 4- 6- . , 3'--5'- ().

I II

. 54.9, Gal-GlcNAc 6 GlcNAc - Gal. I GIcNAc-Asn. .

II , , . Gal-NAc-Thr(Ser).

. 54.12. . , . , 3-- . (Modified redrawn, and reproduced with permission, from Lindahl U. et al. Structure and biosynthesis of heparin-like polysaccharides. Fed. Proc., 1977, 36, 19.)

. , , . , . . 54.12. (GlcN) . GlcN N- , . GlcN 6- .

90% IdUA 10% GlcUA. GlcUA, , 5- 90% GlcUA IdUA, 2- .

, . ; 500015000, 100000.

:

1) , N- (GlcUA-GlcNAc)n; 2) 50% GlcNAc N-; 3) GlcN ; 5-, 90% - -

, . , . , -. - ( ) - , .

, . , . , GlcUA, IdUA, GalN -1,3-. IdUA, , 5- GlcUA. , . , 2 :

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