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. 1- . . : 2, 2, 3 4. 2 2 , 3 4 ( ). . -

. 38.1. , -; 2,5 . (Reproduced with permission, from P. Oudet, M. Gross-Bellard, P. Chambon: Electron microscopic and biochemical evidence that chromatin structure is a repeating unit Cell 1975, 4: 281.)

, N- . : , , , ADP- ( 2) ( ). , , ( ).

. 4 , (32-42). 2 2 (2-2), [2-2]. 32-4, 2-2- . 1 .

, 32-42 2-2 , . - . , , in vitro 2, 2, 3 4 , . 1 .

. .

. 38.2. () (), , 2, 2, 3 4. 1 ( ) . (Reproduced, with permission, from Laskey R. A. and Eamshaw W.C.: Nucleosome assembly. Nature 1980, 286: 763.)

, , . , 32-42-. , 1,75 ( ), 146 (. 38.2). :

1 , 2 , .. 166 . .

, , . , , , . , . , , , , , , . -, , . . . , , . , , .

, -, 1 , . , , .

10 2530 . (. ) 10 5 . -, 10 , (. 38.3). , , 67 . 30 (. 38.4). , . -, , , , , . , . , 30 100 (. ).

, 30000100000 . , , . , , , .

. 38.3. 10 , . 1- .

. 38.4. 30 , 10 . .

, . , . , (- ), . , , . ( 100000 ), (, I). I -- .

(100300 ) ( ) I. , , -, , . , (. . 39 41). , , . , , .

, - () , . - () . (. ) , .

: . , , . , () . , , . - -, . . . - - , , .

, Chironomus, , . , , .

- , , , (. 38.5).

, , (. 38.6). . , . -.

. , 23

. 38.5. - II . (39 , 30 ) Chironomus tentans . . - ( ) . , . - IV . . . IV , -- . - . (Reproduced, with permission, from Sass H. PNA polymerase in polytene chromosomes. Cell 1982: 28: 274. Copyright 1982 by the Massachusetts Institute of Technology.)

. , 8000 ! ( 2530 ) , (-) . , , . 38.1.

, , (. 38.7).

38.1.

() , , , . , .

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