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. 39. , . 5- N- . - . () . . 39, 5- . . , - .

- .

, , : , . (. 40.7)

- 5- , (.39). , , - 40S- . , AUG. 18S-PHK () 408- , . 408- 3 (-3).

-, , GTP 2 (-2). 1 (-1) 40S- . (-1, -2 -3) GTP 60S, GTP. 808- .

. (-) - . (A-) -, . - P-, A- . , . , -, . , , , , 16S (188)- .

, , -ʗN--. - , N- .

, N- , . , N- . .

(. 40.8)

808- A- . - A- . 1 (-1) GTP -. - . -1-GDP . . 40.8, -1-GDP -1-GTP GTP.

- - -, P-. , 608- . - , . , -.

PH P- P-. GTP 2 (-2) - - -. GTP, -2, GDP . - P-, A- - .

, ADP . - A- GTP GDP. - A- - GTP GDP . , ADP

(. )

. 40.7. , - 1, 2 3 . Met -. -- - .

(. )

. 40.8. . . -1 -2 - 1 2 .

GTP GDP, . . .

(. 40.9)

, , - -. , -. - (-). R- GTP -. 808- -, . , , - - -.

. - 80 . , , . , ( , ), . , .

100 .

, , , (). , , . , , . (. . 42). , .

, (- ), , . . - -, . , . . , , (. . 51.4 51.5).

, N- . . ( ) N- . . (. . 56). . , , , , .

, . 37. , . , . i , . ,

(. )

. 40.9. . - - - . -- 2O. N N- - .

40.2. -

, . . 40.2, , .

, (). (). , . 40.10, -. - - . - , .

, Corynebactcrium diphteriae. ADP- -2 . -2 , , . (, ) . , -2 ADP-.

. 40.10. - -.

, , . , .

Burrell . G. et al. Different pattern of codon recognition by mammalian mitochondrial tRNAs, Proc. Natl. Acad. Sci. USA, 1980, 77, 3164.

Cask v . T. Peptide chein termination. Trends Biochem. Sci., 1980. 5. 234.

Darnell J. et al. Molecular Cell Biology, Scientific American Books. 1986.

Drake J. W., Baltz R. H. The biochemistry of mutagenesis, Annu. Rev. Biochem, 1975, 45, 11.

Forget B. G. Molecular genetics of human hemoglobin synthesis, Ann. Intern. Med., 1979, 91, 605.

Heselkkorn R., Rothman-Denes L. B. Protein synthesis, Annu. Rev. Biochem., 1973, 42, 397.

Hunt T. DNA Makes RNA Makes Protein, Elsevier, 1983.

Levin B. Genes, 2nd ed., Wiley, 1985.

Roth J. R. Frameshift mutations, Annu. Rev. Genet, 1974, 8, 319.

Schafritz D. A. et al. Evidence for the role of M7Gs-phosphate group in recognition of eukaryotic mRNA by inhibition factor IF-MV Nature, 1976, 261, 291.

Schlessinger D. Genetic and antibiotic modification of protein synthesis, Annu. Rev. Genet., 1974, 8, 135.

Shatkin A.J. mRNA cap binding proteins: Essential factors for initiating translation. Cell, 1985, 40, 223.

Weatherall D.J., Clegg J. B. Thalassemia revisited, Cell, 1982, 29, 7.

Weissbach G., Ochoa S. Soluble factors required for eukaryotic protein synthesis, Annu. Rev. Biochem., 1976, 45, 191.

Wool I. The structure and function of eukaryotic ribosomes, Annu. Rev. Biochem, 1979, 48, 719.

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